Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation.
Identifieur interne : 000E66 ( Main/Exploration ); précédent : 000E65; suivant : 000E67Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation.
Auteurs : Buranee Kanchanatawan [Thaïlande] ; Sunee Sirivichayakul [Thaïlande] ; Kiat Ruxrungtham [Thaïlande] ; André F. Carvalho [Brésil] ; Michel Geffard [France] ; George Anderson [Royaume-Uni] ; Michael Maes [Thaïlande]Source :
- Molecular neurobiology [ 1559-1182 ] ; 2017.
Abstract
Deficit schizophrenia is accompanied by mucosa-associated activation of the tryptophan catabolite (TRYCAT) pathway, as indicated by increased IgA responses to noxious (NOX) TRYCATs, but not regulatory or protective (PRO) TRYCATs, suggesting increased neurotoxic, excitotoxic, inflammatory, and oxidative potential. No previous studies examined IgM-mediated autoimmune responses to the TRYCAT pathway in deficit versus nondeficit schizophrenia. We measured IgM responses to NOX TRYCATs, namely, quinolinic acid (QA), 3-OH-kynurenine (3HK), picolinic acid (PA), and xanthurenic (XA) acid, and PRO TRYCATs, including kynurenic acid (KA) and anthranilic acid (AA), in 40 healthy controls and 40 deficit and 40 nondeficit schizophrenic patients. We computed the IgM responses to NOX (QA + PA + 3HK + XA)/PRO (AA + KA) ratio and ∆ differences in IgA - IgM TRYCAT values and NOX/PRO ratio. Deficit schizophrenia is characterized by significantly attenuated IgM responses to all TRYCATs and NOX/PRO ratio and highly increased ∆IgA - IgM NOX/PRO ratio as compared to nondeficit schizophrenia and healthy controls. The negative symptoms of schizophrenia are significantly and positively associated with increased IgM responses directed against the KA/3HK ratio and ∆IgA - IgM NOX/PRO ratio. The findings support the view that deficit schizophrenia is a distinct subtype of schizophrenia that may be significantly discriminated from nondeficit schizophrenia. Deficit schizophrenia is accompanied by a highly specific defect in IgM isotype-mediated regulatory responses directed to the TRYCAT pathway. Lowered IgM regulatory responses together with mucosa-derived activation of the TRYCAT pathway may contribute to neuroprogression, negative symptoms, and deficit schizophrenia. All in all, a highly specific defect in the compensatory (anti-)inflammatory reflex system (CIRS), namely, natural IgM-mediated regulatory responses, may underpin deficit schizophrenia.
DOI: 10.1007/s12035-017-0465-y
PubMed: 28290151
Affiliations:
- Brésil, France, Royaume-Uni, Thaïlande
- Angleterre, Aquitaine, Aquitaine-Limousin-Poitou-Charentes, Ceará, Grand Londres
- Bordeaux, Londres, Talence
- Université fédérale du Ceará
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000F28
- to stream PubMed, to step Curation: 000F25
- to stream PubMed, to step Checkpoint: 000F25
- to stream Ncbi, to step Merge: 004459
- to stream Ncbi, to step Curation: 004459
- to stream Ncbi, to step Checkpoint: 004459
- to stream Main, to step Merge: 000E61
- to stream Main, to step Curation: 000E66
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation.</title>
<author><name sortKey="Kanchanatawan, Buranee" sort="Kanchanatawan, Buranee" uniqKey="Kanchanatawan B" first="Buranee" last="Kanchanatawan">Buranee Kanchanatawan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sirivichayakul, Sunee" sort="Sirivichayakul, Sunee" uniqKey="Sirivichayakul S" first="Sunee" last="Sirivichayakul">Sunee Sirivichayakul</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carvalho, Andre F" sort="Carvalho, Andre F" uniqKey="Carvalho A" first="André F" last="Carvalho">André F. Carvalho</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE</wicri:regionArea>
<placeName><region type="state">Ceará</region>
</placeName>
<orgName type="university">Université fédérale du Ceará</orgName>
</affiliation>
</author>
<author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name>
<affiliation wicri:level="3"><nlm:affiliation>IDRPHT, Research Department, Talence, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>IDRPHT, Research Department, Talence</wicri:regionArea>
<placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Talence</settlement>
<settlement type="city" wicri:auto="agglo">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anderson, George" sort="Anderson, George" uniqKey="Anderson G" first="George" last="Anderson">George Anderson</name>
<affiliation wicri:level="3"><nlm:affiliation>CRC Scotland & London, Eccleston Square, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>CRC Scotland & London, Eccleston Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michael" last="Maes">Michael Maes</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. dr.michaelmaes@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28290151</idno>
<idno type="pmid">28290151</idno>
<idno type="doi">10.1007/s12035-017-0465-y</idno>
<idno type="wicri:Area/PubMed/Corpus">000F28</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F28</idno>
<idno type="wicri:Area/PubMed/Curation">000F25</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F25</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000F25</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F25</idno>
<idno type="wicri:Area/Ncbi/Merge">004459</idno>
<idno type="wicri:Area/Ncbi/Curation">004459</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004459</idno>
<idno type="wicri:Area/Main/Merge">000E61</idno>
<idno type="wicri:Area/Main/Curation">000E66</idno>
<idno type="wicri:Area/Main/Exploration">000E66</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation.</title>
<author><name sortKey="Kanchanatawan, Buranee" sort="Kanchanatawan, Buranee" uniqKey="Kanchanatawan B" first="Buranee" last="Kanchanatawan">Buranee Kanchanatawan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sirivichayakul, Sunee" sort="Sirivichayakul, Sunee" uniqKey="Sirivichayakul S" first="Sunee" last="Sirivichayakul">Sunee Sirivichayakul</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carvalho, Andre F" sort="Carvalho, Andre F" uniqKey="Carvalho A" first="André F" last="Carvalho">André F. Carvalho</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE</wicri:regionArea>
<placeName><region type="state">Ceará</region>
</placeName>
<orgName type="university">Université fédérale du Ceará</orgName>
</affiliation>
</author>
<author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name>
<affiliation wicri:level="3"><nlm:affiliation>IDRPHT, Research Department, Talence, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>IDRPHT, Research Department, Talence</wicri:regionArea>
<placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Talence</settlement>
<settlement type="city" wicri:auto="agglo">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anderson, George" sort="Anderson, George" uniqKey="Anderson G" first="George" last="Anderson">George Anderson</name>
<affiliation wicri:level="3"><nlm:affiliation>CRC Scotland & London, Eccleston Square, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>CRC Scotland & London, Eccleston Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michael" last="Maes">Michael Maes</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. dr.michaelmaes@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Molecular neurobiology</title>
<idno type="eISSN">1559-1182</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Deficit schizophrenia is accompanied by mucosa-associated activation of the tryptophan catabolite (TRYCAT) pathway, as indicated by increased IgA responses to noxious (NOX) TRYCATs, but not regulatory or protective (PRO) TRYCATs, suggesting increased neurotoxic, excitotoxic, inflammatory, and oxidative potential. No previous studies examined IgM-mediated autoimmune responses to the TRYCAT pathway in deficit versus nondeficit schizophrenia. We measured IgM responses to NOX TRYCATs, namely, quinolinic acid (QA), 3-OH-kynurenine (3HK), picolinic acid (PA), and xanthurenic (XA) acid, and PRO TRYCATs, including kynurenic acid (KA) and anthranilic acid (AA), in 40 healthy controls and 40 deficit and 40 nondeficit schizophrenic patients. We computed the IgM responses to NOX (QA + PA + 3HK + XA)/PRO (AA + KA) ratio and ∆ differences in IgA - IgM TRYCAT values and NOX/PRO ratio. Deficit schizophrenia is characterized by significantly attenuated IgM responses to all TRYCATs and NOX/PRO ratio and highly increased ∆IgA - IgM NOX/PRO ratio as compared to nondeficit schizophrenia and healthy controls. The negative symptoms of schizophrenia are significantly and positively associated with increased IgM responses directed against the KA/3HK ratio and ∆IgA - IgM NOX/PRO ratio. The findings support the view that deficit schizophrenia is a distinct subtype of schizophrenia that may be significantly discriminated from nondeficit schizophrenia. Deficit schizophrenia is accompanied by a highly specific defect in IgM isotype-mediated regulatory responses directed to the TRYCAT pathway. Lowered IgM regulatory responses together with mucosa-derived activation of the TRYCAT pathway may contribute to neuroprogression, negative symptoms, and deficit schizophrenia. All in all, a highly specific defect in the compensatory (anti-)inflammatory reflex system (CIRS), namely, natural IgM-mediated regulatory responses, may underpin deficit schizophrenia.</div>
</front>
</TEI>
<affiliations><list><country><li>Brésil</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>Thaïlande</li>
</country>
<region><li>Angleterre</li>
<li>Aquitaine</li>
<li>Aquitaine-Limousin-Poitou-Charentes</li>
<li>Ceará</li>
<li>Grand Londres</li>
</region>
<settlement><li>Bordeaux</li>
<li>Londres</li>
<li>Talence</li>
</settlement>
<orgName><li>Université fédérale du Ceará</li>
</orgName>
</list>
<tree><country name="Thaïlande"><noRegion><name sortKey="Kanchanatawan, Buranee" sort="Kanchanatawan, Buranee" uniqKey="Kanchanatawan B" first="Buranee" last="Kanchanatawan">Buranee Kanchanatawan</name>
</noRegion>
<name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michael" last="Maes">Michael Maes</name>
<name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name>
<name sortKey="Sirivichayakul, Sunee" sort="Sirivichayakul, Sunee" uniqKey="Sirivichayakul S" first="Sunee" last="Sirivichayakul">Sunee Sirivichayakul</name>
</country>
<country name="Brésil"><region name="Ceará"><name sortKey="Carvalho, Andre F" sort="Carvalho, Andre F" uniqKey="Carvalho A" first="André F" last="Carvalho">André F. Carvalho</name>
</region>
</country>
<country name="France"><region name="Aquitaine-Limousin-Poitou-Charentes"><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name>
</region>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Anderson, George" sort="Anderson, George" uniqKey="Anderson G" first="George" last="Anderson">George Anderson</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E66 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E66 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:28290151 |texte= Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28290151" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |